Skin boosters
Polynucleotides in London
Skin quality boosters for repair and renewal
Polynucleotide (PN) boosters support the skin’s own repair to improve texture, firmness and dark under-eyes. They add no volume, and the improvement builds over a course of sessions.
Special offer
Brighter under-eyes and healthier skin with polynucleotide boosters, now £169
£169
Polynucleotides · 1 session
4.9 from 251 verified client reviews
The treatment
What are Polynucleotides?
Polynucleotides (PN) are purified DNA fragments injected into the skin to support its own repair, available at PureSkin in Marylebone, London. PN boosters work on the quality of the skin itself: they hydrate, support collagen and elastin, and calm inflammation. Unlike fillers, they add no volume, so your face keeps its shape while your skin looks brighter, firmer and more even over a course of treatments.
- Brightens dark, hollow-looking under-eyes
- Improves crepey skin and fine lines around the eyes
- Firms and hydrates the face and neck
- Evens skin texture and tone
- Adds no volume, so results look natural
Where it works
Treatment areas
Face & neck
- Under-eyes
- Crow’s feet
- Full face
- Neck
Body
- Décolletage
- Hands
The science
How do Polynucleotides work?
Polynucleotides give your skin cells building blocks and signals for repair. Once injected, they encourage fibroblasts to produce collagen and elastin, hold water in the skin and calm inflammation. The improvement is progressive: your skin repairs itself over weeks, so results look like your own skin on a good day.
- 1
Consultation
We assess your skin and under-eyes and check that PN boosters suit you.
- 2
Preparation
We cleanse your skin and apply numbing cream for comfort.
- 3
Micro-injections
We place small amounts of PN booster in the treatment area with a fine needle or cannula.
- 4
Repair
Your skin rebuilds over the following weeks, and each session in the course adds to the last.
Is it right for me?
Who are Polynucleotides for?
- Anyone with dark or hollow-looking under-eyes
- Clients with crepey skin or fine lines around the eyes
- Those with dull, dehydrated or tired-looking skin
- Anyone who wants better skin quality without fillers
Results
What results can I expect?
PN boosters improve your skin over weeks, not overnight. Most clients notice brighter, more hydrated skin during the course, and the improvement keeps building for several weeks after the last session. Your practitioner plans the number of sessions with you, and results vary between individuals.
Prices
How much do Polynucleotides cost?
We confirm your price at the free consultation, before you book anything.
Compare
Polynucleotides compared with other skin treatments
How PN boosters differ from other injectable skin treatments. Typical figures, which vary from person to person:
| Treatment | What it does | Adds volume | Best for |
|---|---|---|---|
| Polynucleotides (PN) | Supports skin repair, collagen and hydration | No | Under-eyes, skin quality |
| Profhilo | Spreads hyaluronic acid to hydrate and firm | No | Laxity and dehydration |
| Dermal fillers | Restores lost volume and structure | Yes | Cheeks, lips, jawline |
| Mesotherapy | Micro-injections of vitamins and hydration | No | Dull, tired skin |
Preparation and aftercare
Before and after your treatment
Before your appointment
- Avoid alcohol for 24 hours before
- Ask your GP before pausing blood-thinning medication
- Tell us about allergies, including to fish, as some PN products come from salmon DNA
- Arrive with clean skin, free of make-up
Aftercare
- Small bumps settle within 1 to 2 days
- Skip make-up on treated areas for 12 hours
- Avoid saunas, heat and intense exercise for 24 hours
- Do not massage or press on the treated area for a few days
- Wear SPF daily
Safety
Side effects and suitability
Common, temporary side effects
- Small raised bumps at injection points for 1 to 2 days
- Mild redness or swelling
- Occasional bruising, most often under the eyes
Not suitable if
- You are pregnant or breastfeeding
- You have a fish or salmon allergy
- You have an active skin infection in the area
- You have an autoimmune condition affecting the skin
Your practitioner checks your medical history at consultation before any treatment.
Questions
Polynucleotides FAQs
What are polynucleotides?
Polynucleotides are purified DNA fragments, often sourced from salmon, used as injectable skin boosters. They support the skin’s own repair by encouraging collagen and elastin production, improving hydration and calming inflammation.
How much do polynucleotides cost in London?
At PureSkin, a polynucleotide booster session costs £169 on our current special offer. Most clients need a course, and we plan yours at a free consultation.
Do polynucleotides work for dark circles?
PN boosters are a popular choice for dark, thin or crepey under-eye skin, because they thicken and brighten the skin without adding volume. Dark circles caused by hollowness or genetics may need a combined plan, which we discuss at consultation.
How many polynucleotide sessions will I need?
Most clients book a course of sessions spaced a few weeks apart, followed by maintenance. Your practitioner sets the number after assessing your skin and goals.
When will I see results from polynucleotides?
Improvement is progressive. Most clients notice brighter, more hydrated skin during their course, and results keep building for several weeks after the final session.
Are polynucleotides the same as fillers?
No. Fillers add volume to reshape areas such as lips or cheeks. Polynucleotides add no volume and focus on the quality of the skin, so your features keep their shape while your skin looks healthier.
What is the difference between polynucleotides and Profhilo?
Profhilo is a hyaluronic acid that spreads under the skin to hydrate and firm. Polynucleotides support the skin’s repair processes and suit delicate areas such as the under-eyes. Some clients combine both as part of one skin plan.
Do polynucleotide injections hurt?
We apply numbing cream first, so most clients feel small pinches. The under-eye area can feel more sensitive, and we use fine needles or a cannula to keep you comfortable.
What are the side effects of polynucleotides?
Small raised bumps at the injection points are normal and settle within 1 to 2 days. Some clients have mild redness, swelling or a small bruise, most often under the eyes.
Who should not have polynucleotides?
Polynucleotides are unsuitable if you are pregnant or breastfeeding, have a fish or salmon allergy, have an active skin infection in the area or an autoimmune condition affecting the skin.
Where can I get polynucleotides in London?
PureSkin offers polynucleotide skin boosters at 11 Welbeck Street, London W1G 9XZ, in Marylebone, a minute from Harley Street and a short walk from Bond Street station. The clinic is open Monday to Saturday, 11am to 7pm.
Ready to book Polynucleotides?
Message us on WhatsApp and we will find you a time, or start with a free consultation.